The results show that AIRBP attains Accuracy (ACC), Balanced Accuracy (BACC), F1-score, and Mathews Correlation Coefficient (MCC) of 95.84 %, 94.71 %, 0.928, and 0.899, respectively, based on the training dataset, using 10-fold cross-validation (CV). Further evaluation of AIRBP on independent test set reveals that it achieves ACC, BACC, F1-score, and MCC of 94.36 %, 94.28 %, 0.897, and 0.860, for Human test set; 91.25 %, 93.00 %, 0.896, and 0.835 for S. cerevisiae test set; and 90.60 %, 90.41 %, 0.934, and 0.775 for A. thaliana test set, respectively. https://www.selleckchem.com/products/sn-52.html These results indicate that the AIRBP outperforms the existing Deep- and TriPepSVM methods. Therefore, the proposed better-performing AIRBP can be useful for accurate identification and annotation of RBPs directly from the sequence and help gain valuable insight to treat critical diseases. Availability Code-data is available here http//cs.uno.edu/?tamjid/Software/AIRBP/code_data.zip.Sentiments associated with assessments and observations recorded in a clinical narrative can often indicate a patient's health status. To perform sentiment analysis on clinical narratives, domain-specific knowledge concerning meanings of medical terms is required. In this study, semantic types in the Unified Medical Language System (UMLS) are exploited to improve lexicon-based sentiment classification methods. For sentiment classification using SentiWordNet, the overall accuracy is improved from 0.582 to 0.710 by using logistic regression to determine appropriate polarity scores for UMLS 'Disorders' semantic types. For sentiment classification using a trained lexicon, when disorder terms in a training set are replaced with their semantic types, classification accuracies are improved on some data segments containing specific semantic types. To select an appropriate classification method for a given data segment, classifier combination is proposed. Using classifier combination, classification accuracies are improved on most data segments, with the overall accuracy of 0.882 being obtained.Clinical decision support assisted by prediction models usually faces the challenges of limited clinical data and a lack of labels when the model is developed with data from a single medical institution. Accordingly, research on multicenter clinical collaborative networks, which can provide external medical data, has received increasing attention. With the increasing availability of machine learning techniques such as transfer learning, leveraging large-scale patient data from multiple hospitals to build data-driven predictive models with clinical application potential provides an alternative solution to address the problem of limited patient data.
A multicenter hybrid semi-supervised transfer learning model (MHSTL) is proposed in this study on the basis of unified common data model to ensure multicenter data standardized representation. Then the hospital-specific features, along with the co-occurrence features across domains, are aligned through a representation learning architecture that is built based is prediction tasks??????. Further exploratory experiments show that the proposed approach exhibits good model generalizability regardless of the data heterogeneity. With the help of the SHapley Additive exPlanations for model interpretation, the effectiveness of incorporating hospital-specific features in the transfer learning model is shown.
In this study, the proposed method can develop prediction models from multiple source hospitals and exhibit good performance by leveraging cross-domain hospital-specific feature information, therefore enhancing the model prediction when applied to single medical institution with limited patient data.
In this study, the proposed method can develop prediction models from multiple source hospitals and exhibit good performance by leveraging cross-domain hospital-specific feature information, therefore enhancing the model prediction when applied to single medical institution with limited patient data.Accurate image segmentation of the liver is a challenging problem owing to its large shape variability and unclear boundaries. Although the applications of fully convolutional neural networks (CNNs) have shown groundbreaking results, limited studies have focused on the performance of generalization. In this study, we introduce a CNN for liver segmentation on abdominal computed tomography (CT) images that focus on the performance of generalization and accuracy.
To improve the generalization performance, we initially propose an auto-context algorithm in a single CNN. The proposed auto-context neural network exploits an effective high-level residual estimation to obtain the shape prior. Identical dual paths are effectively trained to represent mutual complementary features for an accurate posterior analysis of a liver. Further, we extend our network by employing a self-supervised contour scheme. We trained sparse contour features by penalizing the ground-truth contour to focus more contour attentions on the failures.
We used 180 abdominal CT images for training and validation. Two-fold cross-validation is presented for a comparison with the state-of-the-art neural networks. The experimental results show that the proposed network results in better accuracy when compared to the state-of-the-art networks by reducing 10.31% of the Hausdorff distance. Novel multiple N-fold cross-validations are conducted to show the best performance of generalization of the proposed network.
The proposed method minimized the error between training and test images more than any other modern neural networks. Moreover, the contour scheme was successfully employed in the network by introducing a self-supervising metric.
The proposed method minimized the error between training and test images more than any other modern neural networks. Moreover, the contour scheme was successfully employed in the network by introducing a self-supervising metric.Accurate clinical diagnosis of lymph node metastases is of paramount importance in the treatment of patients with abdominopelvic malignancy. This review assesses the diagnostic performance of deep learning algorithms and radiomics models for lymph node metastases in abdominopelvic malignancies.
Embase (PubMed, MEDLINE), Science Direct and IEEE Xplore databases were searched to identify eligible studies published between January 2009 and March 2019. Studies that reported on the accuracy of deep learning algorithms or radiomics models for abdominopelvic malignancy by CT or MRI were selected. Study characteristics and diagnostic measures were extracted. Estimates were pooled using random-effects meta-analysis. Evaluation of risk of bias was performed using the QUADAS-2 tool.
In total, 498 potentially eligible studies were identified, of which 21 were included and 17 offered enough information for a quantitative analysis. Studies were heterogeneous and substantial risk of bias was found in 18 studies. Almost all studies employed radiomics models (n = 20).